10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) The goal of the present study was to provide lessThan i greaterThan in vitro lessThan /i greaterThan evidences for antioxidant and anti diabetic potential of lessThan i greaterThan Trichodesma indicum lessThan /i greaterThan to generate a stronger biochemical rationale for further lessThan i greaterThan in vivo lessThan /i greaterThan studies. The hydroalchohol extract of  lessThan i greaterThan Trichodesma indicum lessThan /i greaterThan whole plant was screened for its lessThan i greaterThan in vitro lessThan /i greaterThan antioxidant activity using 2, 2-Diphenly 1-picryl hydrazyl assay, Scavenging of Nitric oxide and Superoxide radical methods, evaluation of Total antioxidant capacity of the extract and Reducing power assay. Cytotoxic effect of the extract was evaluated by MTT assay and lessThan i greaterThan in-vitro lessThan /i greaterThan antidiabetic effect was studied using the glucose uptake model in rodent skeletal muscle cells (L-6 cells) involved in glucose utilization. The extract of lessThan i greaterThan Trichodesma indicum lessThan /i greaterThan showed good antioxidant properties against 2, 2-Diphenly 1-picryl hydrazyl radical with low IC lessThan sub greaterThan 50 lessThan /sub greaterThan values 135mg/ml and against nitric oxide and superoxide radical exhibited poor scavenging properties with IC lessThan sub greaterThan 50 lessThan /sub greaterThan value of greaterThan 1000mg/ml. The total antioxidant activity which expressed equivalent to Ascorbic acid has 225.28 mg per gram of dried extract. The increased absorbance at 700 nm indicates an increase in reducing power of samples. The drug extract showed percentage growth inhibition value of 500 µg/ml and showed average glucose uptake (P lessThan 0.05) with percentage of glucose uptake of 91.03±10.12 over the control. The extract of lessThan i greaterThan Trichodesma indicum lessThan /i greaterThan  exhibited significant antioxidant activity and moderate antidiabetic activity and merits further investigation in animal models and support traditional claim. SUDHARSHAN REDDY DACHANI, SRINIVASA RAO AVANAPUAND PRADEEP HULIKERE ANANTH Trichodesma indicum, In-vitro antioxidant, Antidiabetic, Glucose uptake and L6 cell lines 810-819