10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) Colchicine is a secondary metabolite, originally extracted from plants of the genius colchicum it consists of the dried ripe seeds of lessThan i greaterThan Colchicum autumnale Linn lessThan /i greaterThan ., colchicine effectively functions as a mitotic poison or spindle inhibitor but the major disadvantage of the colchicine is toxicity and non target cell (normal cell)effect. That toxicity and targeted drug delivery can be controlled by carriers Vesicular systems are a novel means of drug delivery that can enhance bioavailability of encapsulated drug and provide therapeutic activity in a controlled manner for a prolonged period of time. This review describes all aspects of controlled drug delivery including their different controlled drug delivery (niosomes, proniosomes, liposomes, ethosomes),different compositions, the various methods of preparation, methods of characterization, cytotoxicity analysis(MTT assay) and comparative controlled drug delivery analysis. The review also provides detailed information of the various types of controlled drugs that provide reduced toxicity. E.BALASUBRAMANIAN AND T.GAJENDRAN. colchicine, controlled drug delivery, cytotoxicity analysis, 09-26