10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) The present study was aimed at investigating the ameliorative effects of lessThan i greaterThan Vanda testacea (VT) lessThan /i greaterThan in sciatic nerve transection (axotomy)-induced peripheral neuropathy in rats. Adult male albino rats weighing 130-150gm were used for the study, and were divided into five groups and axotomy was performed on left sciatic nerve in group II to group V. Tail cold-hyperalgesia, motor co-ordination, foot deformation tests, and total calcium levels were estimated to assess the extent of neuropathy. Superoxide dismutase (SOD), catalase (CAT), lipid peroxides (LPO), calcium, prostaglandin E2 levels were estimated. Hydro-alcoholic extract of lessThan i greaterThan VT lessThan /i greaterThan was administered at a dose of 175 and 350 mg/kg/p.o for 15 days. lessThan i greaterThan VT lessThan /i greaterThan attenuated sciatic nerve transection-induced motor in-coordination, reversed axotomy-induced alterations in lipid peroxides, total calcium, superoxide dismutase, catalase levels in a dose-dependent manner. Ameliorative effects of lessThan i greaterThan VT lessThan /i greaterThan in axotomy-induced neuropathy may be due to its antioxidant, calcium and prostaglandin attenuating actions. SANTH RANI THAAKUR AND SWAPNA POKKULA Axotomy, Complete sciatic nerve transection, Neuropathic pain, Neuropathy, Vanda testacea. 271-284