10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) The aim of the present study was to evaluate the antilithiatic activity of lessThan i greaterThan Saccharum spontaneum lessThan /i greaterThan Linn. Healthy male Wistar rats were used in the present study and were divided randomly into 5 groups. Group I was served as normal control. Lithiasis was induced in rats by fed with a calculi-producing diet (CPD: commercial diet mixed with 3% glycolic acid) for 28 days (group II). The levels of protein, sodium, potassium, and chloride and lipid peroxidation were altered in urolithiatic rats. Supplementation with ethanolic extract of lessThan i greaterThan S.spontaneum lessThan /i greaterThan (200 and 300 mg / kg body weight) by oral administration for subsequent 28 days at a rate of 1.0 ml / rat / day restored the levels and it brought back the values to near normal range in urolithiatic rats. The results indicate that the ethanolic extract of lessThan i greaterThan S.spontaneum lessThan /i greaterThan is endowed with significant antiurolithiatic activity. Accordingly, it can be concluded that the supplementation of lessThan i greaterThan S.spontaneum lessThan /i greaterThan root has a beneficial effect on urolithiasis induced by glycolic acid. M,SATHYA AND DR. R.KOKILAVANI Saccharum spontaneum, urolithiasis, glycolic acid, protein, sodium potassium chloride 01-10