10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) The cytochrome P lessThan sub greaterThan 450 lessThan /sub greaterThan protective activity of lessThan i greaterThan Sapindus mukorossi lessThan /i greaterThan and lessThan i greaterThan Rheum emodi lessThan /i greaterThan were evaluated against CCl lessThan sub greaterThan 4 lessThan /sub greaterThan induced prolongation of pentobarbitone sleep time in Wister rats. The fractions, at a dose of 0.2 g/kg,0.4g/kg p.o., Sapindus mukorossi, Rheum emodi significantly prevents the CCl lessThan sub greaterThan 4 lessThan /sub greaterThan induced prolongation of pentobarbitone sleep time (P lessThan 0.01), indicating the cytochrome P lessThan sub greaterThan 450 lessThan /sub greaterThan protection activity. However, when treated alone, the fractions (0.2 g/kg and 0.4 g/kg, p.o.) shows a significant prolongation of pentobarbitone sleep time (P lessThan 0.01), indicating the intrinsic cytochrome P lessThan sub greaterThan 450 lessThan /sub greaterThan inhibition activity. In addition, the extracts show neither stimulant nor depressant effect on the CNS, as evident from locomotor activity test. In conclusion, the results indicate that, the Sapindus mukorossi saponin fraction and anthraquinone fraction of rheum emodi at an oral dose of 0.2 g/kg and 0.4 g/kg, p.o., shows significant protective effects against CCl lessThan sub greaterThan 4 lessThan /sub greaterThan induced cytochrome P lessThan sub greaterThan 450 lessThan /sub greaterThan damage and also show a significant intrinsic cytochrome P lessThan sub greaterThan 450 lessThan /sub greaterThan inhibition activity. MEESALA.SRINIVASARAO, PRADEEP.H.A, AND MOHAMMED IBRAHIM Cytochrome P450, Carbon tetrachloride, Sapindus mukorossi saponin fraction, Anthraquinone fraction of Rheum emodi 641-648