10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) The capability of the bio-control agent lessThan i greaterThan Trichoderma harzianum lessThan /i greaterThan to trigger plant growth and improvement in biomass response was investigated by inoculating roots of medicinal plant ( lessThan i greaterThan Ocimum sanctum lessThan /i greaterThan ) seedlings with lessThan i greaterThan Trichoderma harzianum lessThan /i greaterThan in pots, under aseptic, green house environmental conditions. lessThan i greaterThan Trichoderma harzianum lessThan /i greaterThan was isolated from ten different agro climatic zones of Karnataka. Biological and biochemical analysis revealed that inoculation with lessThan i greaterThan T. harzianum lessThan /i greaterThan initiated increased Phosphate (P), Nitrogen (N) and soluble sugars uptake by the lessThan i greaterThan O. sanctum lessThan /i greaterThan plants. Inoculation with lessThan i greaterThan T. harzianum lessThan /i greaterThan increased the biomass of the plants in terms of height, number of leaves and number of branches, providing evidence that lessThan i greaterThan T. harzianum lessThan /i greaterThan induce growth and increased biomass mechanisms in plants. The whole cell protein was extracted from all the ten isolates of lessThan i greaterThan T. harzianum lessThan /i greaterThan and then subjected to electrophoresis (SDS-PAGE). The protein profile on the gel was scored and the dendrogram was constructed using Phylip software of lessThan i greaterThan T. harzianum lessThan /i greaterThan . Exploiting bio-control agents to enhance the plant growth and biomass production of medicinal plants is a topic of current interest. PADMAVATHI TALLAPRAGADA Trichoderma harzianum, Bio-control agent, Ocimum sanctum, biomass, Protein profiling 661-672