10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) Antioxidants have reactive oxygen species (ROS) scavenging ability with great relevance in the prevention of oxidative stress. The present study aimed to examine the antioxidant and ROS scavenging activities of 70% methanolic extract of lessThan i greaterThan Tinospora cordifolia lessThan /i greaterThan . The plant was found a significant source of carbohydrate, alkaloid, ascorbic acid, tannin, phenolic and flavonoid compound. The extract was found to be an antioxidant with a TEAC value of 0.257 ± 0.03. The extract has shown different radical scavenging activity and 128.86± 4.07 µg/ml, 103.17 ± 5.75 µg/ml, 51.98 ± 4.80 µg/ml, 327.38 ± 21.44 µg/ml, were determined as IC lessThan sub greaterThan 50 lessThan /sub greaterThan value for hydroxyl radical, superoxide, nitric oxide, and hypochlorous acid respectively. The plant inhibits lipid peroxidation with an IC lessThan sub greaterThan 50 lessThan /sub greaterThan of 75.86 ± 2.16 µg/ml. The extract also has good DNA protective potential. In other words, the present results provide evidence that lessThan i greaterThan T. cordifolia lessThan /i greaterThan acts as an antioxidant and DNA protector. NIKHIL BABAN GHATE, DIPANKAR CHAUDHURI AND NRIPENDRANATH MANDAL Tinospora cordifolia, radical scavenging, antioxidant, DNA protection 373-388