10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) Milk is a key contributor to improving nutrition and food security. The virtues of milk as a food have long been recognized by human beings. Milk is however a good medium for bacterial growth and an efficient vehicle for bacterial infection when consumed without boiling or pasteurization. The aim of the present study was to evaluvate the presence of ESBL producing lessThan i greaterThan Klebsiella lessThan /i greaterThan species present in raw milk of Doon valley in India. The study was carried out from July 2007 to July 2008. A total of 100 samples of raw milk were collected from Doon valley. These samples were cultured and the isolated organisms were identified by standard bacteriological methods. A total of 27 samples were found to be positive for lessThan i greaterThan Klebsiella lessThan /i greaterThan species. Further ESBL phenotypic screening was performed. All 27 isolates found ESBL producing. Isolated lessThan i greaterThan Klebsiella lessThan /i greaterThan lessThan i greaterThan spp lessThan /i greaterThan showed 96.29% susceptibility to imipenem followed by ciprofloxacin (62.96%), piperacillin/tazobactam combination (51.85%) and ciftazidime (18.51%). This study reveals that lessThan i greaterThan Klebsiella lessThan /i greaterThan isolated from raw milk in Doon valley produce ESBL in large proportion. The imipenem antibiotic which was found highly sensitive to ESBL producing lessThan i greaterThan klebsiella lessThan /i greaterThan isolates might be a drug of choice. S. CHAUHAN, U. FAROOQ, V. SINGH AND AJAY KUMAR ESBL, antibiotic resistance, Klebsiella pneumonia, raw milk. 417-423