10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) lessThan i greaterThan Phoenix dactylifera linn lessThan /i greaterThan ( lessThan i greaterThan Arecaceae lessThan /i greaterThan ) commonly known as Date palm has been widely used in Siddha system of medicine for diabetes. The powder form of dried dates ( lessThan i greaterThan Karchure chooranam lessThan /i greaterThan ) showed a significant inhibitory effect was screened at 500mg/kg, for the in vivo anti-diabetic activity on alloxan induced diabetic rats. Glibenclamide (10mg/kg) used as reference standard. Single dose (500 mg/kg) treatment with the siddha drug Karchure chooranam produced 69.34% anti-hyperglycaemic effect (antidiabetic effect). The trial drug showed a significant anti-diabetic activity (P lessThan 0.01) and were comparable with that of standard thus validating the traditional claim of the plant. K. NANDHAGOPAL, M.KANNIYAKUMARI, , J. ANBU AND V.VELPANDIAN Phoenix dactylifera linn, Siddha system, Glibenclamide, Anti-diabetic activity, Alloxan 434-439