10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) To develop a RP-HPLC method for the simultaneous determination of eight active ingredients including hydrochlorothiazide (HCTZ), metoprolol succinate, valsartan, losartan Potassium, benazepril hydrochloride, telmisartan, amlodipine besylate and atorvastatin in pharmaceutical products. METHOD: HPLC analysis was carried out by using a XTerra C18 column with the gradient mobile phase composed of Sol-A: ammonium acetate buffer (1.4g of ammonium acetate in to 1000ml of HPLC water) and sol-B: acetonitrile with simple gradient program (0-5min, sol-A:88-85; 5-10min- sol-A:85-70; 10-18min- sol-A:70-70; 18-25min- sol-A:70-55; 25-30min- sol-A:55-88 and 30-35min- sol-A:88-88). Flow for mobile phase elution is 1.0ml per min; column oven temperature is maintained at 35°C and record the absorbance with 230nm.RESULT: The co-relation coefficient for all eight active ingredients is not less than 0.999. The average recoveries of the all components were 98.0% to 102.0%.CONCLUSION: This HPLC method is simple, quick and reproducible, with high recovery and has been successfully applied to the simultaneous determination of the eight components in pharmaceutical drug products. PHANI.R.S.CH, K.R.S. PRASAD AND USENI REDDY MALLU Hydrochlorothiazide (HCTZ), Metoprolol succinate, Valsartan, Losartan Potassium, Benazepril hydrochloride, Telmisartan, Amlodipine besylate, Atorvastatin, Hypertensive drugs, Cardiovascular drugs and RP-HPLC method development and validation. 440-454