10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) Doxorubicin (DOX) (also known as hydroxyl daunorubicin or Adriamycin) is a cytotoxic, anthracycline antibiotic drug isolated from the soil fungus lessThan i greaterThan Streptomyces peucetius caesius lessThan /i greaterThan . DOX is widely used as intravenous antimitotic neoplastic to treat wide range of solid tumours. It has been shown to produce reproductive abnormalities in males. Silymarin (SYL), a flavanolignan compound extracted from seeds of 'milk thistle' ( lessThan i greaterThan Silybum marianum lessThan /i greaterThan ), is an antioxidant well known for its hepatoprotective action. The present study was aimed to evaluate the protective effect of SYL on DOX induced testicular toxicity in rats. SYL was administered at a dose of 100mg/kg, 200mg/kg, and 300mg/kg to rats which are simultaneously given DOX (3mg/kg) to induce testicular toxicity. The treatment was given for a period of 5 weeks. SYL treatment maintained near normal levels of sperm count, testicular spermatid head concentration, daily sperm production, Serum testosterone levels and normal spermatogenesis when compared to positive control. VIJAY KRANTI.M, MAHESH.V, SRINIVAS.P, Y.V.GANESH , AJAY GODWIN.P AND DR. MANGALA LAHKAR Doxorubicin, Chemotherapy, Silymarin, Hepatoprotective action, and Flavanolignan. 473-484