10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) Hydantoin, which is chemically imidazolidin dione is present in many biologically active moieties. Some of the well known anticonvulsant agents contain hydantoin scaffold. In the present work some novel derivatives of hydantoin were synthesized using Blitz reaction and all the synthesized compounds were evaluated for antibacterial and antifungal activities. A total of eight compounds was synthesized and all the synthesized compounds were characterized using chromatographic and spectral analysis. Some of the novel compounds synthesized exhibited mild to moderate anti bacterial and antifungal activity when compared with the standard. The compounds should be taken for detailed biological activity studies for the development of effective and safe antimicrobial agents. VINOD.B , SELVAKUMAR.D, AND BINCY.K.CHACKO. Hydantoin, Blitz reaction, Diphenyl imidazolidin, Benzil,Semicarbazide 759-767