International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 2
2013 (April - June)
EFFECT OF FREE AND BOUND FLAVONOIDS FROM WRIGHTIA TINCTORIA (ROXB) R. BR. LEAVES ON SKIN PATHOGENS
The causative agents of skin infection are bacteria, fungi and in specific dermatophytes. Many infectious diseases have been treated with plant extracts. The free and bound flavonoids fractions of lessThan i greaterThan Wrightia tinctoria (Roxb) lessThan /i greaterThan R.Br. (Apocynaceae), leaves were tested against 10 bacterial, 3 fungal and 4 dermatophytic strains affecting the skin using disc diffusion and broth micro dilution method. The free flavonoidal extract showed maximum activity against lessThan i greaterThan Bacillus subtilis lessThan /i greaterThan (gram positive), lessThan i greaterThan Proteus vulgaris lessThan /i greaterThan (gram negative), lessThan i greaterThan Candida albicans lessThan /i greaterThan (fungus) and lessThan i greaterThan Trichophyton rubrum lessThan /i greaterThan (dermatophyte). The bound flavonoidal extract showed maximum activity against lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan (gram positive), lessThan i greaterThan Escherichia coli lessThan /i greaterThan (gram negative), lessThan i greaterThan Candida albicans lessThan /i greaterThan (fungus) and lessThan i greaterThan Epidermophyton floccosum lessThan /i greaterThan (dermatophytes) among the various tested organisms. The bounded flavonoidal extract (activity index 0.58) had strong activity against dermatophytes. This provides a lead that, flavonoidal extract could be used for direct incorporation into formulations for effective treatment and a scientific rationale for the traditional use of lessThan i greaterThan Wrightia tinctoria lessThan /i greaterThan in treating skin infections.
T. SENTHIL KUMAR, D. VENKAPPAYYA,VILAMBI N.R.K. REDDY AND R. MANAVALAN.
Antibacterial AntifungalAntidermatophytic Flavonoidal extractsWrightia tinctoria (Roxb.) R. Br.
889-897