10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) Mevastatin, also known as compactin or ML-236B is a member of the class of statins belonging to the polyketide group. Polyketides are rich sources of pharmaceuticals, including antibiotics, anticancer drugs, and cholesterol-lowering drugs, immunosuppressants and other therapeutics lessThan sup greaterThan [1]. lessThan /sup greaterThan This study was performed for the production of mevastatin using sesame oil cake as substrate with lessThan i greaterThan Pencillium citrinum lessThan /i greaterThan MTCC 1256 by Solid State FermentationThe present study was carriemevastatin by solid state fermentation with lessThan i greaterThan Pencillium citrinum lessThan /i greaterThan MTCC 1256 using sesame oil cake. Different agro residues as substrates and different organisms were screened and various physico-chemical parameters were optimized. In this paper we explained in detail on the four significant factors i.e, fermentation time (X lessThan sub greaterThan 1 lessThan /sub greaterThan , days), temperature (X lessThan sub greaterThan 2 lessThan /sub greaterThan , lessThan sup greaterThan o lessThan /sup greaterThan C), pH (X lessThan sub greaterThan 3 lessThan /sub greaterThan ), nitrogen source (X lessThan sub greaterThan 4 lessThan /sub greaterThan ,%w/v), which significantly influence the production of mevastatin were selected by using Plackett-Burman statistical design. These variables were further optimized using a 2 lessThan sup greaterThan 4 lessThan /sup greaterThan full factorial CCD (Central Composite Design) and a second order polynomial model equation was obtained. In the present study the value of the regression coefficient lessThan i greaterThan R lessThan /i greaterThan lessThan sup greaterThan 2 lessThan /sup greaterThan = 0.9938 which indicates that 99.38% of the variability in the response could be explained by the model. The adjusted R lessThan sup greaterThan 2 lessThan /sup greaterThan value is 0.9859 which is also very high to advocate the significance of the model. N. HARSHA, V. SRIDEVI, M.V.V. CHANDANA LAKSHMI AND K.VIJAY KUMAR Mevastatin, Pencillium citrinum MTCC 1256, Fermentation time, Temperature, pH, Nitrogen source, Carbon source. 392-401