10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) Three simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Aceclofenac (ACE) and Thiocolchicoside (THI) in their combined dosage form. Method A,Simultaneous equations method involves measurement of absorbance at 275 nm for ACE and 254 nm for THI, Method B,Absorption Ratio method involves measurement of absorbance at 275 nm for ACE and 264 nm for THI & Method C,Ratio first order derivative method involves measurement of amplitude at 265 nm for ACE and 240.60 nm for THI. Methanol used as a solvent. In these three UV spectrophotometric methods, first method linearity lies between 5-30 μg/mL for both ACE & THI, while for second and third method linearity lies between 10-35 μg/mL for both ACE & THI respectively with correlation coefficient greaterThan 0.998. The methods were validated according to ICH Guidelines. All validation parameters were within the acceptable range. These developed methods can be applied for routine analysis. N B GOTECHA Aceclofenac,Thiocolchicoside,Simultaneous Equations Method, Q-Absorbance ratio method, Ratio First Derivative Method. 778-785