10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) The present study was designed to screen the antidepressant potential of lessThan i greaterThan Vanda spathulata lessThan /i greaterThan  using forced swim test and tail suspension test. Imipramine (30mg/kg) and Fluoxetine (20mg/kg) were used as standard drugs. The vehicle (10ml/kg, p.o), fluoxetine (20mg/kg, i.p.), imipramine (30mg/kg, i.p.) and lessThan i greaterThan Vanda spathulata lessThan /i greaterThan  (100mg/kg, 200mg/kg and 400mg/kg, p.o. respectively) were administered for 14 days. Duration of immobility was noted in both the models. In our study, both imipramine and lessThan i greaterThan Vanda spathulata lessThan /i greaterThan significantly reduced the duration of immobility was obseved when compared to control group. The antidepressant activity of lessThan i greaterThan Vanda spathulata lessThan /i greaterThan was comparable to that of standard drug impramine. Significant decrease in brain MAO-A and MAO-B activities levels were observed upon methanolic extract administration to mice as compared to control. Therefore, methanolic extract of lessThan i greaterThan Vanda spathulata lessThan /i greaterThan showed significant antidepressant activity probably by inhibiting MAO-A and MAO-B. Hence, methanolic extract of lessThan i greaterThan Vanda spathulata lessThan /i greaterThan may be explored further for the management of mental depression. RAJANEEKAR DASARI, D. SATHYAVATHI, SAMPATH KUMAR BELIDE AND B.R.SOUMYA Vanda spathulata, Antidepressant, MAO, Forced swim test, Tail suspension test. 866-872