International Journal of Pharma and Bio Sciences
ijpbs.net
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10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 3
2013 (July - September)
INCRETIN ANALOGUE, LIRAGLUTIDE A NEWER TREATMENT APPROACH FOR TYPE-2 DIABETES MELLITUS.
Glucagon-like peptide 1 (GLP-1) receptor agonists, are one among the latest addition of medication included for the management of type 2 diabetes. Liraglutide, a novel long acting glucagon-like peptide analogue, is effective at improving indices of glycemic control. It has good tolerability and safety profile. It acts in a glucose-dependent manner. In controlled trials, it was observed that it produce short –term glucose lowering effects, with the reduction of HbA1C of up to 1.3 % which is comparable with oral agents. The beneficial effects observed for liraglutide was on reduction of weight (1-3.4 kg) and blood pressure (2.1-6.7mmHg). The formation of antibodies against Liraglutide was comparatively less than that of exenatide. The effects of liraglutide on beta-cell function, cardiovascular risk and disease progression are anticipated from long-term clinical trials results. There are on-going or in development trials exploring the effects of liraglutide in prediabetes, obesity and type 1 diabetes.
BINILA T BALAGOPAL AND SIBY JOSEPH
Incretin, GLP-1 analogue, Liraglutide.
890-896