10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) Vascular complication with long time duration represents the main cause of morbidity and mortality in diabetic patients. Total 125 subjects were enrolled for the study. In study group of Diabetic patients were randomly given 400 mg of vitamin E once a day in a blind manner out of 95 patients. The present study was to investigate the role of alpha tocopherol and oxidative stress in diabetic vascular complications patients. Free radical determination was done by estimation of SOD, Catalase and MDA. In present study significant high units of catalase and MDA and lower units of SOD were found in patient .Alpha tocopherol administration results in faster reduction of oxidative stress. Antioxidant vitamin such as vitamin E might help in prevention of vascular complications in diabetes. GUPTA VANI AND KUMAR SANDEEP Vitamin E, MDA, Catalase, SOD and Diabetes 1065-1074