10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) BNP, B type natriuretic peptide, an established marker of heart failure, also has a role to play in obesity and diabetes. The phenomenon of natriuretic handicap ( i.e., reduced / impaired natriuretic peptide response is common among type II diabetes mellitus patients.Our aim was to investigate the clinically meaningful associations which implicated low serum BNP levels with obese type II diabetes mellitus patients.The association between low BNP levels and diabetes in the study population supports the phenomenon of natriuretic handicap and so its predisposition to hypertension and other cardiovascular disorders and thereby BNP levels can be assessed as a routine in obese diabetics to assess their status of natriuretic response. DR.B.SHANTHI , DR.K.GUNANITHI AND DR.A.J.MANJULA DEVI Brain natriuretic peptide, Type II diabetes mellitus, Natriuretic peptide clearance receptors, Visceral fat, Body mass index. 1389-1392