International Journal of Pharma and Bio Sciences
ijpbs.net
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10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 4
2013 (October - December)
DEVELOPMENT OF ANALYTICAL METHOD FOR DETERMINATION OF LISINOPRIL TABLETS USING RP-HPLC METHOD
A high performance liquid chromatographic method was developed, validated and applied for determination of lisinopril in pharmaceutical formulations. A LiChrospher lessThan sup greaterThan ® lessThan /sup greaterThan RP-18 (10 µm, 250x 4 mm) column was used with a mobile phase consisting of acetonitrile: phosphate buffer (30: 70% v/v, pH 2.0), a quantitative evaluation was performed at 215 nm with flow rate of 1 mL/min, and column cooler temperature was maintained at 35 ºC. The retention time was about 6 min. This method is suitable for assay of lisinopril tablets and it can be applied in routine quality control, as it is accurate, precise and simple.
V.MASLARSKA AND J. TENCHEVA
Lisinopril, RP-HPLC method, Validation, Quality control
163-167