10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) An efficient, simple clean synthesis of Schiff bases of some aminobenzoic acid/ aminopyridine with ketone (acetyl acetone / cyclohexanone) and benzaldehyde were done by an ultrasound irradiation method as well as conventional method. The major advantages of ultrasonication are short reaction time, operational simplicity, high yield, easy workup and environment friendly procedure. The isolated compounds obtained from both the methods were compared and characterized by IR and NMR spectral data. These were screened against certain strains of bacteria and fungi and showed significant anti microbial activity. ANJALI JHA, SHABANA YASHMEEN AND D N KUMAR amino benzoic acid/ pyridine, Schiff bases, ketone, benzaldehyde, ultrasonication, antimicrobial activity. 197-204