International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 1
2014 (January - March)
COMPARATIVE STUDY OF EFFECTS OF COMBINATION OF METFORMIN + GLIMEPIRIDE VS METFORMIN + GLIMEPIRIDE + PIOGLITAZONE IN TYPE 2 DIABETES MELLITUS PATIENTS.
Metformin belongs to biguanides, Glimepiride is a second-generation sulfonylurea, Pioglitazone belongs to thiazolidinediones type of oral hypoglycaemic drugs. A prospective randomized open labelled parallel study was conducted in Type II Diabetes Mellitus patients. One group received Metformin and Glimepiride (M+G) where as another group received Metformin, Glimepiride and Pioglitazone (M+G+P) for 12 weeks. Baseline investigations were carried out before and after the study. The data was statistically analysed using students 'T' test. M+G+P group showed a significant fall (p lessThan 0.05) in fasting and post prandial blood glucose , giycosylated haemoglobin (p lessThan 0.05), significant rise ( p lessThan 0.05) in high density lipoprotein, better patient compliance and follow up compared to M+G group. There was no significant difference in triglycerides, low density lipoprotein levels in both the groups. Gastrointestinal side effects were more in M+G group while pedal oedema, hypoglycaemic episodes were more in M+G+P group.
CH.V.NAGANJANI AND V. SUSMITHA
Metformin, Glimepiride, Pioglitazone, blood glucose, Giycosylated haemoglobin, High density lipoprotein.
212-218