10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 2 2010 (April - June) Traditionally aerial parts of Barleria prionitis Linn. has been used in the inflammation, fever & toothache. The present study was undertaken to evaluate the anti-inflammatory and anti-nociceptive activity of 50% ethanolic extract of the flower of B. prionitis (BPF) in experimental animals. The BPF in doses of 50, 100 and 200 mg/kg caused a dose-dependent inhibition of swelling caused by carrageenin equivalent to 17.8–48.6% protection (P greaterThan 0.05–P lessThan 0.001) and in cotton pellet granuloma, 46.2–36.4% protection (P lessThan 0.01-P lessThan 0.001) was observed from inflammation. There was a significant increase in analgesio meter force induced pain in mice equivalent to 26.3–48.23% protection (P lessThan 0.01P lessThan 0.001) & 5.24 - 34.6 % (P lessThan 0.05–P lessThan 0.001) protection against Acetic acid induced writhing. Our results shows that flower of B. prionitis possess significant anti-inflammatory and anti-nociceptive activity.  lessThan br / greaterThan Sunil K. Jaiswal,Mukesh K. Dubey,Sanjeeb Das,Arti R. Verma,M. Vijayakumar,Chandana V. Rao Barleria prionitis; Anti-inflammatory; Anti-nociceptive; cotton pellet granuloma -