International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 4
2014 (October - December)
ANTIBACTERIAL ACTIVITY OF ANTHRAQUINONE ENCAPSULATED CHITOSAN/POLY(LACTIC ACID) NANOPARTICLES
The aim of this research is to evaluate antibacterial activities against multi drug resistance pathogens with the prepared anthraquinone (AQ) coated polymeric nanoparticles, chitosan (CS) and poly(lactic acid)(PLA) (CS/PLA-AQ NPs). The preliminary and cold stability study was determined for its drug loading capacity, encapsulation efficiency and lessThan i greaterThan in vitro lessThan /i greaterThan drug release behaviour using UV spectrophotometer. The formulation (CS/PLA-AQ NPs) was tested for its antibacterial effect by disc diffusion method and Minimum bactericidal Concentration (MBC) on Gram negative bacteria's ( lessThan i greaterThan Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae lessThan /i greaterThan and lessThan i greaterThan Proteus vulgaris lessThan /i greaterThan ) which was found to have higher activity when compared to CS-PLA NPs and bare AQ. The results specified that the nanoparticles formulation is a possible applicant to be considered as an antimicrobial agent lessThan i greaterThan in vitro lessThan /i greaterThan .
JEEVITHA D , MALATHY BR , PRADEEP PS AND SRIVIDYA S
Antibacterial, Anthraquinone, Chitosan, MBC, Poly(lactic acid), Stability.
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