10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 4 2014 (October - December) In the present study the protective effects of lessThan i greaterThan Aegle mamelos lessThan /i greaterThan fruit extract AMF were carried out in somatic cells of mice against doxyrubicin induced genotoxicity. Three different doses of lessThan i greaterThan Aegle Marmelos lessThan /i greaterThan fruit extract were tested for the antimutagenicity using the micronucleus test in bone marrow cells of mice. The test compound doxyrubicin higher dose 16 mg/kg was injected intrapertioneally prior to the administration of plant extract. The lessThan i greaterThan Aegle Marmelos lessThan /i greaterThan fruit extract did not induce micronuclei significantly by all the three doses tested where as doxyrubicin induced significant increase in the frequency of micronuclei in bone marrow erythrocytes of mice. Pre treatment of mice with AMF for 7 days and simultaneously with a single dose of doxyrubicin, there was a significant inhibition in the percentage of micronuclei was found thus lessThan i greaterThan Aegle Marmelos lessThan /i greaterThan fruit extract modulates the doxyrubicin induced cytotoxicity in a dose dependent way. Thus the overall results suggest the protective nature of lessThan i greaterThan Aegle Marmelos lessThan /i greaterThan fruit extract, it is a safer dietary antioxidant as cancer chemopreventive therapy. K. RUDRAMA DEVI AND CH. PRABAKAR REDDY Doxyrubicin, Genotoxicity, Aegle Mamelos Fruit Extract, Micronuclei, Mice 276-282