STUDIES ON 5-CYANOURACILS: EXPEDIENT SYNTHETIC PROTOCOL FOR SYNTHESIS OF NOVEL PYRIDO[2,3-d]PYRIMIDINE AND PYRIMIDO [4,5-d]PYRIMIDINE ANALOGS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY

10.22376/ijpbs.2019.10.1.p1-12

Volume 5 Issue 4 2014 (October - December) STUDIES ON 5-CYANOURACILS: EXPEDIENT SYNTHETIC PROTOCOL FOR SYNTHESIS OF NOVEL PYRIDO[2,3-d]PYRIMIDINE AND PYRIMIDO [4,5-d]PYRIMIDINE ANALOGS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY Novel, diverse pyrido [2,3-d] pyrimidine and pyrimido [4,5-d] pyrimidine analogs were synthesized by the reaction of 1,3-substituted-5-cyano uracil derivatives with appropriate nucleophile under mild conditions. Utilising 5-cyano uracil with various substitutions as a substrate leads to rapid synthesis of annulated uracils with diverse biological properties. YOGESH Y. PEDGAONKAR, ARUNDHATI C. LELE, NUTAN H. PALSULE DESAI AND MARIAM S. DEGANI Cyanouracils, pyrido[2,3-d]pyrimidine, pyrimido[4,5-d]pyrimidine, multicomponent. 422-439