10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 4 2014 (October - December) Four novel random copolyesters were synthesized from a common diol (diol I) namely 2,5 ditertiarybutyl hydroquinone and the varying diol (diol II) namely 3,3 lessThan sup greaterThan ' lessThan /sup greaterThan -(1,4-phenylene)bis(1-(4-hydroxyphenyl)prop-2-en-1-one) (THAP) and 3,3 lessThan sup greaterThan ' lessThan /sup greaterThan -(1,4-phenylene)bis(1-(4-hydroxy-3-methoxy phenyl)prop-2-en-1-one) (TMAP) and succinyl and glutary chloride by solution polycondensation. The two varying diols were synthesized using Acid catalyzed Claisen-Schmidt reaction. The copolyesters obtained were characterized by qualitative solubility tests and viscosity values. Their structure was confirmed by FTIR, lessThan sup greaterThan 1 lessThan /sup greaterThan H and lessThan sup greaterThan 13 lessThan /sup greaterThan C NMR spectra. These copolyesters displayed potential antimicrobial activity against bacterial strains. T.S.PERUNDEVI, D. REUBEN JONATHAN AND S. KOTHAI Bischalcone, Polycondensation, Copolyester, Bactericidal 528-533