International Journal of Pharma and Bio Sciences
ijpbs.net
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 4
2014 (October - December)
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME NEW 2,6-DIARYLPIPERIDIN-4-ONE DERIVATIVES
Acetic acid promoted one-pot Mannich type condensation involving long chain ketones results in the formation of 3-substituted or 3,5-disubstituted 2,6-diarylpiperidin-4-ones in moderate yields. In the absence of acetic acid, the reaction does not proceed to completion. The six member heterocyclic ring adopts a chair conformation, with equatorial disposition of all the substituents. Among the different derivatives of piperidine-4-one, derivatives containing tetrazole and semicarbazone are more potent than the alkyl derivatives against bacteria and fungi.
R. SRIKANTH, A. SIVARAJAN AND B. SIVAKUMAR
2,6-diarylpiperidin-4-ones; Mannich reaction; semicarbazone; Antimicrobial activity.
543-551