10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 4 2014 (October - December) To evaluate the association of lipoproteins & apolipoproteins with Coronary artery disease (CAD) in patients with (CAD-DM lessThan sup greaterThan + lessThan /sup greaterThan ) & without Type II Diabetes mellitus (CAD-DM lessThan sup greaterThan - lessThan /sup greaterThan ) and to determine better risk predictor, we conducted a case-control study. 40 patients with clinical and angiographic evidence of CAD (20 diabetics, 20 non-diabetics) and 20 healthy controls were drawn for the study. Significantly high total cholesterol(TC), Triglycerides(TG), low density cholesterol(LDL-C), TC/HDL-C were observed in CAD-DM lessThan sup greaterThan + lessThan /sup greaterThan patients but no significant differences were found in CAD-DM lessThan sup greaterThan - lessThan /sup greaterThan patients when compared with controls. On the other hand, levels of ApoB/A-I(apolipoproteinB/ apolipoproteinA-I) and apoB were significantly high in both groups. When comparison was done between two CAD groups, significantly higher(p lessThan 0.001) levels of ApoB/A-I and apoB were observed in diabetics compared to non-diabetics. In ROC analysis between CAD-DM lessThan sup greaterThan + lessThan /sup greaterThan vs. controls, maximum AUC was found for apoB/A-I(0.9975) and apoB(0.9925) compared to LDL-C(0.8425), TC/HDL-C(0.7913). Between CAD-DM lessThan sup greaterThan - lessThan /sup greaterThan and controls, AUC for apoB/A-I(0.81) was maximum compared to apoB(0.6575), LDL-C(0.6313) and TC/HDL-C(0.5613). These findings suggest that ApoB/A-I is a better predictor of risk for CAD whether associated with DM or not, and is superior to traditional lipid markers in patients without DM. NOORJAHAN MOHAMMED, AMBIKA DEVI.K, RAMARAO JANYAVULA, BHASKAR RAJU.D.S AND SAI BABA SS KOMPELLA ApolipoproteinA-I; ApolipoproteinB; ApolipoproteinB/ApolipoproteinA-I ratio; Coronary artery disease (CAD); Diabetes mellitus (DM) 1062-1071