10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 4 2014 (October - December) Native lessThan i greaterThan Xenorhabdus lessThan /i greaterThan lessThan i greaterThan Sp lessThan /i greaterThan was isolated from the Entomopathogenic Nematodes lessThan i greaterThan Steinernema lessThan /i greaterThan lessThan i greaterThan Sp lessThan /i greaterThan used as a biopesticide for the control of malarial vectors. The lessThan i greaterThan Xenorhabdus lessThan /i greaterThan bacterium which is symbiotically associated with lessThan i greaterThan Steinernema Sp lessThan /i greaterThan has a wider range of toxic proteins lessThan i greaterThan lessThan /i greaterThan secreted in the medium. Most of the protein secreted by the bacteria are extra cellular proteins of the Outer Membrane Vesicles (OMVs) of this gram negative bacteria plays an important role in killing the host larvae. The molecular weight of the OMV proteins of the isolates of lessThan i greaterThan Xenorhabdus Sp lessThan /i greaterThan ranges from 20-97 KDa. This bacterium is proved to be an insect pathogen with an excellent source of insecticidal agents of proven toxicity. The outer membrane vesicles of this bacteria act as natural bombs by transporting virulence factors into the host. The novel approach of our present study includes the biopesticidal approach of the OMVs proteins from the isolated strains of lessThan i greaterThan Xenorhabdus lessThan /i greaterThan lessThan i greaterThan Sp lessThan /i greaterThan from the sugarcane fields in Tamilnadu against third instar lessThan i greaterThan Anopheles gambiae lessThan /i greaterThan mosquito larvae, which transmits lessThan i greaterThan Plasmodium lessThan /i greaterThan causes a major infectious disease called Malaria.100 ng/ml of OMV protein treated against the larvae recorded maximum mortality (93.32%) with the isolates XBS21 and XNHS 12 (76%). This was the first report showing the biopesticidal property of the OMV proteins of the isolates of lessThan i greaterThan Xenorhabdus lessThan /i greaterThan lessThan i greaterThan Sp lessThan /i greaterThan against the malarial vectors. VANI C AND LALITHAMBIKA B Xenorhabdus Sp, Outermembrane Vesicle Proteins, Anopheles gambiae, Malaria 1072-1080