10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 4 2014 (October - December) The aim of the study is to evaluate the therapeutic applications of silver nanoparticles synthesized using 2 medicinal plants collected from yelagiri hills. The leaves of the plants were used for optimization of silver nanoparticles by varying the time exposure of the reaction mixture to sunlight (5, 10, 15 minutes). The anti-oxidant, anti inflammatory and antimicrobial potentials of samples was studied by different assays. Also, the synthesized nanoparticles were characterized by UV, SEM, XRD and FTIR techniques. The results suggest that nanoparticles synthesis was significant at exposure time of 5 and 10minutes. The synthesized particles were confirmed by UV spectroscopy, which showed a characteristic peak at 427 and 418nm for the 2 samples respectively. The synthesized nanoparticles were found to be in the size range of 60-80nm and possessed characteristic XRD peaks. The results of the study revealed that the synthesized silver nanoparticles possessed significant antioxidant, anti inflammatory, anti-proliferative and antimicrobial properties. GIRIDHARAN.T , CHANDRAN.M , SINDHU.S AND ARUMUGAM.P Flacourtia sepiaria, Rhinacanthus nasutus, SEM, XRD, FTIR, MCF7 cells. 560-569