10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) The antibacterial activity of lessThan i greaterThan Citrus karna lessThan /i greaterThan fruit peel extracts was evaluated on bacteria strains like lessThan i greaterThan Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus lessThan /i greaterThan and lessThan i greaterThan Bacillus subtilis. lessThan /i greaterThan Hexane, chloroform and methanol were used for extraction and the antibacterial activity was performed by agar well diffusion method. The results were compared with ampicillin, a commercial antibacterial agent. Methanolic extract shows the highest antibacterial activity against all the four bacterial strains, whereas hexane extract shows lowest antibacterial activity. Among the tested bacterial isolates lessThan i greaterThan P. aeruginosa lessThan /i greaterThan was the most inhibited majorly with the methanol extract. The methanolic extract shows lowest (14mm) zone of inhibition against lessThan i greaterThan B. subtilis lessThan /i greaterThan . The chloroform extract displayed inhibitory zones of between 12-15mm while the hexane extract exhibited inhibitory affinity between 11-13mm. The MIC of the plant extracts on the susceptible bacterial isolates was between 37-333µg/ml. Present study concludes that fruit peels of lessThan i greaterThan Citrus karna lessThan /i greaterThan have a broad spectrum antibacterial activity against human pathogens. SIKANDER DAR AND REENA S LAWRENCE Citrus karna fruit peel extracts, Antibacterial activity, zone of inhibition, MIC 261-266