PROTEIN MODELING AND DRUG DOCKING STUDIES ON ROTEIN TARGET OF EAE IUNTIMIN (E COLI)) BY BIOACTIVE ONSTITUENTS OF PHYLLANTHUS EMBLICA

10.22376/ijpbs.2019.10.1.p1-12

Volume 6 Issue 1 2015 (January - March) PROTEIN MODELING AND DRUG DOCKING STUDIES ON ROTEIN TARGET OF EAE IUNTIMIN (E COLI)) BY BIOACTIVE ONSTITUENTS OF PHYLLANTHUS EMBLICA The background of the present lessThan i greaterThan Insilico lessThan /i greaterThan studies, was to find out the potential protein target in Eae lessThan i greaterThan iuntimin (E coli) lessThan /i greaterThan and deliver the 3 D structure and to find out the best inhibitors of the virulence protein. Alkaloids from medicinally important plant lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan ( lessThan i greaterThan Phyllantidine and Phyllanthine lessThan /i greaterThan ) were used for the above purpose using molecular drug docking techniques. The lessThan i greaterThan Phyllanthine lessThan /i greaterThan , lessThan i greaterThan Phyllantidine lessThan /i greaterThan and the commercial antibiotic gentamicine potentially inhibited the target protein Eae lessThan i greaterThan iuntimin (E coli) lessThan /i greaterThan . Based on the molecular drug docking and binding affinities of the target protein Eae lessThan i greaterThan iuntimin (E coli) lessThan /i greaterThan it was found that the Amla alkaloid lessThan i greaterThan Phyllanthine lessThan /i greaterThan showed high binding values than lessThan i greaterThan Phyllantidine lessThan /i greaterThan and the existing drug lessThan i greaterThan Gentamicine. lessThan /i greaterThan S.K.SUNDAR AND S.U.ANUSHA Drug docking, Virulence factor, Alkaloids 297-304