10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) The aim of the present study is to prepare and characterize Solid Lipid Nanoparticles (SLNs) encapsulated Chrysin (CN) to improve the bioavailability of the drug. Chrysin-loaded solid lipid nanoparticles (CN-SLNs) with an average particle size of 240.0± 4.79nmand a total drug content of 71.10 ± 3.12% was produced using a hot homogenization followed by micro emulsion technique. The prepared CN-SLNs were also characterized using zeta potential, entrapment efficiency, X-Ray Diffraction (XRD), Transmission Electron Microscope (TEM) and cytotoxicity assay. The particles were found to be spherical in shape, with high drug entrapment of 86.29 ± 3.42%. Zeta potential studies confirmed the stability of the CN-SLNs preparation as indicated by the negative charge (-40.4 ± 2.54 mV). Whereas the XRD studies showed reduced crystallinity and the particles showed less cytotoxic effect when compared with other polymeric nanoparticles (IC lessThan sub greaterThan 50 lessThan /sub greaterThan value = 25.0 ± 2.16 µg/ml).The in-vitro release kinetics showed a maximum drug release of 88.80 ± 3.05% for CN-SLNs and 39.28 ± 3.19% of Chrysin suspension(CN–S) in 72 hrs, which ensures the controlled drug release property of CN-SLNs. VEDAGIRI AISHWARYA, RAMACHANDRAN SUREKHA AND THANGARAJAN SUMATHI Solid lipid nanoparticles, Chrysin, Dynamic light scattering, Entrapment efficiency, Transmission Electron Microscope. 465-478