10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) A series of 5-substituted phenyl-N-(6-(propylthio)-1H-benzo[d]imidazol-2-yl)-1, 3, 4-oxadiazol-2-amines were prepared by treating substituted 2-benzylidene-N-(6-(propylthio)-1H-benzo[d]imidazol-2-yl) hydrazine carboxamides with Chloramine T.The newly synthesized derivatives were screened against anti-inflammatory activity using COX kit.The compounds showed dose dependent activity. The compounds which showed better lessThan i greaterThan in-vitro lessThan /i greaterThan activity tested for lessThan i greaterThan in-vivo lessThan /i greaterThan activity using Carrageenan rat paw edema method. K.BLESSI PRIYANKA,B.SHOBARANI AND G.SAMMAIAH benzimidazole, oxadiazole, carrageenan, rat paw edema method. 499-505