10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) The purpose of the present study was to evaluate and compare the effect of nonsurgical periodontal therapy on salivary proteins in subjects with periodontitis and compare it with healthy subjects. A total of 30 subjects in age group between 30 and 45 years were enrolled, of which 15 had generalized severe Chronic Periodontitis (CP), and 15 periodontally healthy as a control (C). The clinical parameters included Plaque index (PI), Gingival index (GI), Pocket probing depth (PPD) Bleeding on probing (BOP) and Clinical attachment loss (CAL). Paraffin wax stimulated whole saliva was collected and immediately centrifuged at -4 lessThan sup greaterThan 0 lessThan /sup greaterThan C, assayed for salivary protein content using the Biuret Bicinchonic Acid protein assay reagent (BCA Kit)., both at baseline and at 4 week following scaling and root planing. Salivary proteins were significantly higher in Generalized Chronic Periodontitis subjects (p lessThan 0.05) as compared to control. After one month of scaling and root planing the salivary protein concentration between pre and post-periodontal therapy improved significantly (p lessThan 0.05).Subjects with established periodontitis exhibited elevated concentrations of salivary protein, suggesting that monitoring for change in salivary composition may be useful tool to establish favorable response to periodontal therapy. DR ANAMIKA SHARMA BDS, MDS , DR S NAGTILAK, M.Sc, Ph.D, BRIG (DR.) B.P. KHATTAK, VSM, BDS, MDS, DR GANESH SINGH, Ph.D, STATISTICS AND DR TANVEER BANO, MBBS, M.D Periodontitis, Salivary protein, Plaque index, Gingival index, Host response. 306-314