10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) This study investigated the prevalence of methicillin-resistant lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan (MRSA) and methicillin sensitive lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan in infected diabetic foot ulcers of 100 patients. Pus samples were collected and they were cultured by using appropriated methods. The lessThan i greaterThan S. aureus lessThan /i greaterThan was the most common pathogen among the Gram-positive bacteria isolated from ulcers. Of the 65 lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan isolated, 50 (76.92%) were found to be Methicillin resistant (MRSA) and 15 (23.07%) were Methicillin sensitive (MSSA). Methicillin resistance lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan were tested for vancomycin resistance. It was concluded that patients with diabetes for long duration (more than 10-15 yrs) with high blood sugar level (350-450mg/dl) were predominantly affected and the foot ulcers were significantly higher in males (80%). The Methicillin resistance lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan (MRSA) was sensitive to vancomycin and lessThan i greaterThan lessThan /i greaterThan imipenem lessThan i greaterThan lessThan /i greaterThan antibiotics and lessThan i greaterThan lessThan /i greaterThan the minimum inhibitory concentration (MIC) of vancomycin for MRSA is 0.01mg concentration and MIC of methicillin for MSSA is 60 mg concentration. J. UMASANKARI, M.C. VANITHA AND C. SEKAR Diabetes, Diabetic foot ulcer, Microbial infection, MRSA, MSSA 468-474