10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) To determine the effectiveness of Liquoirce root extract lollipops in reducing the S.mutans count in the saliva of children aged 6-12 yrs using both Culture plating method and Dentocult. Study design; Pilot study Methods; Supervised administration of Liquorice root extract lollipops was given twice daily for 10 days to 10 children aged 6-12 yrs in a primary school setting. Baseline counts and the post intervention counts were compared using Culture plating methods and Dentocult method. Statistics were carried out using non parametric analysis. Results; The post intervention counts when compared to baseline values showed a significant reduction in the S.mutans colonies. Conclusion; Liquorice promises a simple yet effective caries prevention method for high risk children. But further studies need to be carried out in a larger group of population. DR.JYOTSNA SRINATH, DR.GARGI.S AND DR.VICTOR SAMUEL antimicrocial therapy, liquorice root lollipop, Streptococcus mutans 935-939