10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) lessThan i greaterThan Clerodendrum infortunatum lessThan /i greaterThan leaves extract have been studied for their potential antibacterial, antifungal, free radical scavenging, α amylase and α glucosidase activity. The properties of ethanol and chloroform extracts were analyzed by lessThan i greaterThan in-vitro lessThan /i greaterThan techniques. The antimicrobial activity of lessThan i greaterThan C.infortunatum lessThan /i greaterThan was performed by disc diffusion method in which the ethanol extract was exhibited significant antibacterial activity against lessThan i greaterThan Bacillus subtillis lessThan /i greaterThan (12.00mm), lessThan i greaterThan Aeromonas hydrophila lessThan /i greaterThan (4.67 mm), lessThan i greaterThan Shigella boydii lessThan /i greaterThan (10.67 mm), lessThan i greaterThan Escherichia coli lessThan /i greaterThan (8.00 mm) and lessThan i greaterThan Staphylococcus lessThan /i greaterThan lessThan i greaterThan .aureus lessThan /i greaterThan (10.00 mm), and antifungal activity against lessThan i greaterThan Trichophyton mentagrophytes lessThan /i greaterThan (9.00mm), lessThan i greaterThan Fusarium oxysporum lessThan /i greaterThan (13.00mm), lessThan i greaterThan Penicillium chrysogenum lessThan /i greaterThan (11.34mm), lessThan i greaterThan Aspergillus niger lessThan /i greaterThan (14.67mm) and lessThan i greaterThan Aspergillus flavus lessThan /i greaterThan (7.34mm). The qualitative analysis of photochemical showed the presence phenolics, alkaloids, flavonoid, saponin, tannin and anthraquinone on both ethanolic and chloroform extracts. Furthermore, to evaluate α-amylase and α-glucosidase inhibitory effect of lessThan i greaterThan C. infortunatum lessThan /i greaterThan extracts, the extracts were subjected to lessThan i greaterThan in-vitro lessThan /i greaterThan inhibition studies with the enzymes α-amylase and α-glucosidase. The ethanolic extract of lessThan i greaterThan C.infortunatum lessThan /i greaterThan showed high inhibition in both α-amylase (17.25%) and α-glucosidase activities. The results provided a platform for the use of lessThan i greaterThan C. infortunatum lessThan /i greaterThan for therapeutics. RAMYA DEVI.K.T AND PRAVEEN KUMAR. S Clerodendrum infortunatum, anti bacterial, antifungal, α-amylase. 1281-1291