10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 1 2015 (January - March) The root of lessThan i greaterThan Bridelia ferruginea lessThan /i greaterThan is traditionally used as a treatment for type 2 diabetes. The objective of this study was to evaluate the effect of lessThan i greaterThan Bridelia ferruginea lessThan /i greaterThan root bark ethyl acetate fractions (EA) on streptozotocin-induced diabetes and identify some chemical compounds. Ethyl acetate fraction (25 and 50 mg/kg/day) was administrated to streptozotocin-induced (60 mg/kg) diabetic mice for 3 weeks. Oral glucose tolerance test and biochemical parameters were estimated at the end of the study. Chemical composition of EA was analysed using HPLC/DAD/MS and lessThan sup greaterThan H lessThan /sup greaterThan NMR. The level of fasting blood glucose, triglycerides (TG), total cholesterol (TC) insulin and glucose intolerance in streptozotocin-induced diabetic mice were significantly (P lessThan 0.01) reduced after daily oral administration of ethyl acetate fraction at the dose of 50mg/kg/day (EA lessThan sub greaterThan 50 lessThan /sub greaterThan lessThan b greaterThan ) lessThan /b greaterThan for 21 days compared to diabetic control mice. EA lessThan sub greaterThan 25 lessThan /sub greaterThan showed only a significant (p lessThan 0. 01) reduction of TG. After chemical analysis, Epigallocatechin (EGC), Epigallocatechin gallate (EGCG) and derivates were identified from the ethyl acetate fraction of lessThan i greaterThan Bridelia ferruginea lessThan /i greaterThan . In conclusion these catechins and derivates can be some antidiabetic compounds of this plant according to their properties in the literature. BATOMAYENA BAKOMA1*, BÉNÉDICTE BERKÉ2,KWASHIE EKLU-GADEGBEKU3 AND NICHOLAS MOORE Bridelia ferruginea, Epigallocatechin, Streptozotocin, Diabetes, HPLC/MS and NMRH 843-853