International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 3
2015 (July - September)
POTENTIAL OF OXALIS CORNICULATA LINN IN THE TREATMENT OF ULCERATIVE COLITIS
lessThan i greaterThan Oxalis corniculata lessThan /i greaterThan Linn (Oxalidace) is an Indian medicinal plant which is widely used as food and folk medicine. Present work was aimed to check the potential of lessThan i greaterThan Oxalis corniculata lessThan /i greaterThan Linn leaf extract in the treatment of ulcerative colitis. Dried and powdered leaves were extracted using petroleum ether, chloroform, ethyl acetate and methanol. The extracts at a dose of 100 mg/kg were screened for acetic acid induced ulcerative colitis in mice. The antioxidant potential of extracts was evaluated by DPPH method. It was observed that liver and kidney functions were not affected in mice after administration of ethyl acetate and methanol extract for fifteen days. Treatment with ethyl acetate extract of lessThan i greaterThan Oxalis corniculata lessThan /i greaterThan Linn showed superior antiulcer, antioxidant activity and better protective effect compared to other extracts. Myeloperoxidas and malondialdehyde level in blood and tissue was decreased significantly after administration of ethyl acetate and methanol extracts in mice.
SANTOSH B. DIGHE , B. S. KUCHEKAR AND SAGAR B. WANKHEDE
Oxalis corniculata Linn. Ulcerative colitis, Myeloperoxidase, Malondialdehyde
117-125