10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 4 2015 (October - December) Aim To evaluate the possible pathways of the anti-depressant activity of naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) in albino mice using the forced swimming test model. Material and methodsThe mechanism of action involved in the anti-depressant activity of naringenin in various doses (20mg/kg &50mg/kg,p.o.) was investigated by observing the effect of naringenin after pre-treatment with fluoxietine prazosin and haloperidol. para-chlorophenylalanine (p-CPA) was also used as a serotonin synthesis inhibitor .Results lessThan b greaterThan lessThan /b greaterThan The results of forced swim test of naringenin significantly attenuated the duration of immobility induced by fluoxietine(15mg/kg/i.p. selective serotonin reuptake inhibitor) ,Haloperidol (0.2mg/ kg, i.p., a classical D2-like dopamine receptor antagonist) and, Prazosin (1mg/kg, i.p., an α-1-adrenoceptor antagonist) and p-chlorophenylalanine (100 mg/kg, i. p, × 3 days; an inhibitor of serotonin synthesis) .Conclusion lessThan b greaterThan lessThan /b greaterThan It can be concluded that naringenin possess potential antidepressant activity (through dopaminergic, noradrenergic and serotonergic mechanisms) and has therapeutic potential in the treatment of CNS disorders RUPASRI DUTT-ROY, KAYALVIZHI E, MANIKANDAN B,DAMEL LAKSHMI AND CHANDRASEKHAR M Depression, Forced swimming test, Naringenin, Serotonin, Nor- adrenalin Dopamine. 119-127