10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 4 2015 (October - December) Marine biofouling is a serious problem caused by the accumulation and settlement of microbial slimes, diatoms, barnacles, tunicates, bryozoans etc., on the hulls of seafaring vessels. In the present study, an attempt has been made to investigate the antifouling potential of marine Polycheates interaction against the settlement of cyprid larvae of lessThan i greaterThan B. amphitrite lessThan /i greaterThan . The crude extract of Polycheate lessThan i greaterThan Capitella capitata lessThan /i greaterThan significantly inhibited the cyprid larval settlement (P lessThan 0.5) than the control. The EC lessThan sub greaterThan 50 lessThan /sub greaterThan value of the crude extract (8 mg/ml) was lower than all the fractions. At higher concentration (16mg/ml), the crude extract of Polycheate lessThan i greaterThan Capitella capitata lessThan /i greaterThan strongly inhibited the larval settlement JADHAV S. S. Biofouling, Polycheate Capitella capitata, B. amphitrite 283-286