10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 4 2015 (October - December) Tetrazoles are the hetrocyclic compounds having diverse biological activities such as analgesic, anti-inflammation, antimicrobial, anticancer, antidiabetic etc., and an impending source in biosciences. lessThan i greaterThan Invivo lessThan /i greaterThan analysis was carried out on anti-inflammatory property of synthesized five tetrazole derivatives (a, b, c, e and g) which revealed that the compound(g) exhibited potential anti-inflammatory activity of 49% when compared to standard Indomethacine at10µg/ml in the previous report by the authors.In the present investigation, molecular docking studies were performed for the above tetrazole derivatives to evaluate the lessThan i greaterThan in- silico lessThan /i greaterThan anti-inflammatory activity against Cycloxigenase-2 (COX-2) protein as model compound and the data was compared with Indomethacine R. ARULMOZHI , HELEN P. KAVITHA, N.ABIRAMI AND R.ARUL MURUGAN Inflammation, Tetrazoles, paw oedema method, Indomethacine, COX-2protein. 522-529