10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 4 2015 (October - December) Diverse acyclic and cyclic g lessThan i greaterThan - lessThan /i greaterThan pyridinyl amines derivatives were easily lessThan i greaterThan de novo lessThan /i greaterThan prepared once more using respective aldimines derived from commercially available g lessThan i greaterThan - lessThan /i greaterThan pyridine carboxyaldehyde and anilines. Obtained secondary amines were tested as possible antioxidant agents with acetylcholinesterase (AChE) inhibitory activity. Both types of amines exhibited a good antioxidant activity and moderate AChE inhibitory properties. Two compounds 4-methoxy- lessThan i greaterThan N lessThan /i greaterThan -(pyridin-4-ylmethyl) aniline lessThan b greaterThan 3c lessThan /b greaterThan and 4-methyl-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline lessThan b greaterThan 5a lessThan /b greaterThan , showed highest the Trolox® Equivalent Antioxidant Capacity (TEAC) values (TEAC = 1.896 and 1.252, respectively), superior than those of α-tocopherol, well-known antioxidant (TEAC = 0.888). The best AChE inhibitor with IC lessThan sub greaterThan 50 lessThan /sub greaterThan of 48.3 µM (8.9 µg/mL) was the lessThan i greaterThan N lessThan /i greaterThan -(pyridin-4-ylmethyl) aniline. From comparative antioxidant/AChE tests, it was identified the 4-methoxy- lessThan i greaterThan N lessThan /i greaterThan -(pyridin-4-ylmethyl) aniline lessThan b greaterThan 3c lessThan /b greaterThan with suitable bio-parameters for design and development of new pyridine-based molecules with dual activity, antioxidant/AChE inhibitory capacities. LEONOR Y. VARGAS MÉNDEZ AND VLADIMIR V. KOUZNETSOV* Pyridinyl amines, antioxidant agents, AChE inhibitory properties 765-771