International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 4
2015 (October - December)
Computational Approaches To Study Dissolution Kinetics And Their Profiles Similitude Of Quetiapine Fumarate
In this paper the purpose was to describe the kinetics of drug dissolution of six different formulations and using different approaches to compare their dissolution profile. Model independent approaches, including the pair wise procedure, ratio test procedures were used to characterize the drug dissolution profiles. Different mathematical models (zero order, first order, Higuchi model, Weibull model, Hixson Crowell, Korsmeyer-Peppas model) were applied to dissolution data of different formulations. The most appropriate model was chosen from the criteria goodness of fit based on R lessThan sup greaterThan 2 lessThan /sup greaterThan , AIC.
RITU AND DR. USHA CHOUHAN
Quetiapine Fumarate, Model dependent Approach, Model independent Approach, goodness of fit.
94-100