<?xml version="1.0" encoding="utf-8"?>
<Journal>
<Journal-Info>
<name>International Journal of Pharma and Bio Sciences</name>
<website>ijpbs.net</website>
<email>editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com</email>
</Journal-Info>
<article>
<article-id pub-id-type='other'>10.22376/ijpbs.2019.10.1.p1-12</article-id>
<issue_number>Volume 6 Issue 4</issue_number>
<issue_period>2015 (October - December)</issue_period>
<title><b>Potential Role Of Vitamin D Deficiency In Nonalcoholic Steatosis</b> </title>
<abstract>Hypovitaminosis D is a wide spread and largely under recognizedpresent day epidemic. Since vitamin D undergoes activation in the liver, hepatic steatosis thought to be caused primarily due to insulin resistance can play a role in vitamin D deficiency. Hence the present study was conducted in 75 adult non diabetic patients in the age group of 25-55(45 males, 30 females) with hepatic steatosis. Liver function tests were estimated in the plasmaspectrophotometrically. Vitamin D was determined by ECLIA. Study groups included vitamin D deficient (group I), insufficient (group II) and sufficient groups (group III). Plasma ALT , ALP and total bilirubin levels were significantly higher in group I and II compared to group III patients. However, AST/ALT ratio was significantly higher groupIII compared to others. Plasma bilirubin and ALT showed significant negative correlation with vitamin D (r=-0.553,p=0.01) and AST/ALT ratio showed a positive correlation. The inverse association of vitamin D and hepatic markers attributes a possible hepatoprotective role of vitamin D. Patients with risk of impaired liver function need to be screened for vitamin D deficiency and its supplementation may prove beneficial.</abstract>
<authors>SUDHA K, RESHMA K AND SOUPARNIKA</authors>
<keywords>Vitamin D, Steatosis, Liver function tests</keywords>
<pages>133-137</pages>
</article>
</Journal>
