10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 4 2015 (October - December) The aim of this research is to throw light on the therapeutic properties of lessThan i greaterThan Jatropha curcas lessThan /i greaterThan leaves methanolic extract in CCl lessThan sub greaterThan 4 lessThan /sub greaterThan -intoxicated female rats as compared to silymarin drug. Female rats were injected with CCl lessThan sub greaterThan 4 lessThan /sub greaterThan (0.5 ml/kg body weight) suspended in olive oil (1:9 v/v) twice a week for six consecutive weeks induced hepatic toxicity. lessThan i greaterThan J. curcas lessThan /i greaterThan methanolic extract and silymarin drug were orally administrated at doses of 250 and 50 mg/kg body weight, daily for one month. Creatinine, urea, inflammatory biomarkers; C-reactive protein (C-RP), tumor necrosis factor alpha (TNF-α) and interlukin-10 (IL-10) levels were measured in rats blood serum. Moreover, histopathological investigation of kidney was performed. The present results reveal that creatinine, urea, C-RP and TNF-α levels were significantly increased in CCl lessThan sub greaterThan 4 lessThan /sub greaterThan -intoxicated rats with percentages 49.54, 76.83, 90.59 and 62.73%, respectively. However, IL-10 level showed a significant decrease with percentage 49.05%. However, the current results declare that administration of intoxicated rats with 250 mg/kg b.wt. methanolic extract of lessThan i greaterThan J. curcas lessThan /i greaterThan showed amelioration in the levels of creatinine, urea, C-RP, TNF-α and IL-10 with percentages of improvement reached to and 56.36, 73.99, 78.39, 54.34 and 39.43%, respectively which were documented with the ameliorative effect of lessThan i greaterThan J. curcas lessThan /i greaterThan extract on renal architectures. Thus, the present results clearly indicated that, oral administration of lessThan i greaterThan J. curcas lessThan /i greaterThan extract might provide an alternative approach for ameliorating nephrotoxicity associated with CCl lessThan sub greaterThan 4 lessThan /sub greaterThan toxicity. FAROUK K. EL-BAZ, HANAN F. ALY AND SAFAA A. SAAD Jatropha curcas, CCl4, Inflammatory biomarkers, Histopathology, Silymarin 146-157