10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 4 2015 (October - December) Human Immunodeficiency Virus is caused by retrovirus in human beings, where the overall immune system fails resulting in opportunistic infections, HIV-1 Reverse Transcriptase (RT) is an important enzyme supporting replication cycle of HIV. Reverse Transcriptase protein an essential focus in the current medications for HIV-1, because of flexible nature of the target proteins, there is a basic need to find novel, powerful medications against HIV. Henceforth, an endeavor has been made to screen ZINC compound Library, Using e-HiTS software in docking process with nevirapine bound HIV-RT, 884 ligands with alike properties were tested for their binding affinity towards targeted enzyme and at last 39 hits were reported as effective inhibitors of HIV-RT Virus. Dr. PVRD PRASADA RAO AND Dr.K.RAMAMOHANA RAO Retrovirus, Nevirapine, Virtual Screening, e-HITS and ZINC database. 1190-1196