International Journal of Pharma and Bio Sciences
ijpbs.net
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10.22376/ijpbs.2019.10.1.p1-12
Volume 7 Issue 1
2016 (January - March)
SYNTHESIS OF NOVEL PYRAZOLINES BEARING TRICHLOROPHENYL MOIETY AS ANTIMICROBIAL AGENTS
In view of developing novel and effective antimicrobial agents, novel series of pyrazolines (4a-g and 5a-g) bearing 2,3,4-trichlorophenyl moiety were synthesized by treating 1-(2,3,4-trichlorophenyl)-3-(4-aryl)-2-propene-1-ones (3) with hydrazine hydrate and formic acid/ acetic acid (Schemes 1 and 2). The newly synthesized compounds were characterized by elemental analysis and spectroscopic studies and screened for their lessThan i greaterThan in vitro lessThan /i greaterThan antibacterial and antifungal activities. The screening studies revealed that the novel pyrazoline derivatives (4a-g and 5a-g) exhibited moderate to good activity.
LAXMANA K, SURESH P. NAYAK, JAGADEESH PRASAD D, PRAKASH ANIL CASTELINO, KUMARA CHALUVAIAH AND SUCHETHA KUMARI
Formylpyrazoline, Acetylpyrazoline, Antimicrobial Activity, Spectroscopic Data.
32-39